Fasudil Slows Development of Cavernous Malformations

RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.

BACKGROUND AND PURPOSE We sought to compare the effect of chronic treatment with commonly tolerated doses of Fasudil, a specific RhoA kinase (ROCK) inhibitor, and simvastatin (with pleiotropic effects including ROCK inhibition) on cerebral cavernous malformation (CCM) genesis and maturation in 2 models that recapitulate the human disease. METHODS Two heterozygous murine models, Ccm1+/-Msh2-/-...

Cavernous malformations.

Cavernous malformations (CMs) are vascular lesions found in the central nervous system (CNS) and throughout the body and have been called cavernomas, cavernous angiomas, and cavernous hemangiomas. This article discusses the epidemiology, natural history, diagnosis, treatment and follow-up of children who are found to harbor these lesions. CMs affect children by causing hemorrhage, seizure, foca...

Pathology of cavernous malformations

Cerebrovascular malformations are classified as cavernous malformations (CMs), arteriovenous malformations (AVMs), developmental venous anomalies (DVAs) and capillary telangiectasias (CTs). CMs are the second most common form of cerebrovascular malformation and constitute up to 10–15% of the total [1,2]. In the past, CMs were not visualized on radiological examinations such as CT scanning or an...

Radiosurgery for cavernous malformations.

The role of radiosurgery for cavernous malformations of the brain remains to be fully defined. We have used Gamma Knife radiosurgery for selected patients with symptomatic, hemorrhagic malformations in high-risk brain locations. Indications, techniques, and results are presented.

Cerebral cavernous malformations.